Mymetics Corp (MYMX)

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Characteristics of Insect Cell Baculovirus Expression Vector System
2021-12-03
Insect cell baculovirus expression vector system (IC-BEVS) is one of the four major expression systems (insect cell, bacterial, yeast and mammalian cell expression systems).

With various advantages, IC-BEVS is an important source for the development of new drugs, materials and reagents, widely used for the study of recombinant protein expression[1], production of human and veterinary vaccines and for pharmaceutical application. For example, both Cervarix, GlaxoSmithKline's cervical cancer vaccine and Flubolk, Sanofi's tetravalent influenza vaccine adopt IC-BEVS.

The recombinant COVID-19 vaccine (Sf9 cell), jointly developed by WestVac Biopharma Co., Ltd. and the State/National Key Lab of Biotherapy, West China Hospital of Sichuan University, is also based on IC-BEVS, where the genes of SARS-CoV-2 are introduced into insect cells multiplied in the culture solution to prepare the SARS-CoV-2 S protein, inducing the human body to produce antibodies to block the viral infection. In addition, for the new generation vaccine against Delta and Omicron variants, WestVac has precisely designed the subunit vaccine antigen with stable self-assembled trimeric sequence, on the mature IC-BEVS platform. The vaccine has shown excellent immunogenicity and safety.

http://www.westvacpharma.com/detail/33